The study investigated the role of organizational practices and employee perspectives in enhancing operational efficiency at Dangote Flour Mill, Apapa, Lagos. The research adopted a descriptive survey design to explore the experiences and opinions of workers regarding key operational processes. The target population comprised all employees of the organization, from which a sample of 100 workers was selected for the study. Data were collected using a structured questionnaire divided into sections capturing demographic information and responses to research questions, measured on a four-point Likert scale. The validity of the instrument was ensured through expert review and content validation, while data were analyzed using frequency tables, percentages, and the Chi-Square (χ²) statistical method to test the hypotheses. Findings from the study revealed that effective organizational practices and employee engagement significantly influence operational efficiency. The study also highlighted areas where improvements in communication, training, and knowledge management could further enhance productivity. Based on these findings, recommendations were made for the implementation of targeted training programs, adoption of systematic knowledge management practices, and fostering a culture of continuous improvement. The study provides valuable insights for organizational managers and policymakers seeking to enhance workforce performance and operational effectiveness, while also laying a foundation for further research on organizational efficiency in industrial settings.